Cleaved PARP (Asp214) Polyclonal Antibody-BS80385

Cleaved PARP (Asp214) Polyclonal Antibody Sizes: 50µl, 100µl Catalogue Numbers: BS80385-50, BS80385-100 Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Swiss-Prot: Q921K2 Host: Rabbit Reactivity: Mouse Applications: WB All Applications: WB,1:1000 - 1:2000 Background: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen a