(KO Validated) PHD2/EGLN1 Polyclonal Antibody - E-AB-90883

(KO Validated) PHD2/EGLN1 Polyclonal Antibody Sizes: 60μL, 120μL, 200μL Catalogue Numbers: E-AB-90883-60, E-AB-90883-120, E-AB-90883-200 Citations, Manuals and MSDS Available upon request. Abbreviation: PHD2/EGLN1 Target Synonym: EGLN1; C1orf12; ECYT3; HALAH; HIF-PH2; HIFPH2; HPH-2; HPH2; PHD2; SM20; ZMYND6 Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism Conjugation: Unconjugated Host: Rabbit Species Reactivity: Human, Mouse, Rat Application: WB, IHC, IF Isotype: IgG Clonality: Polyclonal UNIProt ID: Q9GZT9 Background: The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits fo