CD357 (AITR/GITR) Monoclonal Antibody (DTA-1), Super Bright™ 702, eBioscience™

PRODUCT DETAILSHost: RatIsotype: IgG2b, kappaClonality: MonoclonalClone: DTA-1Format: Super Bright™ 702Reactivity: MouseApplication: Flow CytometryTested Dilution: 0.3 µg/testConcentration: 0.2 mg/mLStorage: 4° C, store in dark, DO NOT FREEZE!Formulation: PBS, pH 7.2, containing 0.09% sodium azidePurification: Affinity chromatographyData Sheet: TDS Specific InformationDescription: The DTA-1 monoclonal antibody reacts with mouse GITR, Glucocorticoid-Induced TNFR family gene, also known as TNFRSF18. In naive mice, GITR is expressed predominantly by CD4+CD25+ T regulatory cells (Treg) and by CD25+ CD4+ CD8- thymocytes. Stimulation of GITR with DTA-1 antibody abrogates Treg cell-mediated suppression. Although it does not deplete CD357 expressing cells in vivo, it has been shown to induce tumorogenesis. The removal of GITR-expressing Treg cells or the administration of DTA-1 resulted in organ specific autoimmune disease.Applications Reported: This DTA-1 antibody has been reported for use in