cFluor^® BYG667 Anti-Human CD193 (CCR3) (5E8)

The 5E8 monoclonal antibody binds to human CD193, also known as CC-chemokine receptor 3 (CCR3), CC CKR3, MIP1-alpha receptor like-2, and eotaxin receptor. CD193 is a member of the G protein-coupled seven transmembrane receptors family, and binds to the CC chemokines eotaxin, eotaxin-2, and eotaxin-3 with high affinity. CD193 has also been reported to bind RANTES, MCP-3, and MCP-4 with low affinity. CCR3 receptor is expressed on human eosinophils, basophils, mast cells, mononuclear phagocytes, platelets, CD34+ hematopoietic progenitor cells, Th2-like lymphocytes, and keratinocytes. CCR3 is thought to play a role in allergic diseases such as bronchial asthma and allergic rhinitis. CCR3 is a co-receptor for HIV-1 and HIV-2, and the binding of eotaxin with CCR3 has been shown to inhibit HIV infection in some cell type PRODUCT DETAILS Clone:          5E8 Reactivity:       Human Format:        cFluor® BYG6671 Isotype:               Mouse IgG2b, κ Tested Dilution:  5 μL / test Application: