PAI-1 Gene Polymorphism

Diagnostic Lab Test:  Plasminogen Activator Inhibitor-1 (PAI-1) Gene Polymorphism   Plasminogen Activator Inhibitor-1 (PAI-1) Gene Polymorphism refers to variations in the gene that encodes the PAI-1 protein, a key regulator of the fibrinolytic system. The PAI-1 gene, officially known as SERPINE1, is responsible for producing the PAI-1 protein, which inhibits tissue plasminogen activator (tPA) and urokinase (uPA), enzymes critical for breaking down blood clots. Polymorphisms in the PAI-1 gene can influence the expression levels and activity of the PAI-1 protein, thereby affecting an individual’s propensity for thrombotic events and various other health conditions. Analyzing PAI-1 gene polymorphisms provides valuable insights into genetic predispositions related to cardiovascular health, metabolic disorders, and other systemic conditions. Certain polymorphisms in the PAI-1 gene, such as the 4G/5G variant, are associated with altered PAI-1 levels. The 4G allele is linked to higher PAI-