Apigenin™ 30 capsules nuBioAge

Apigenin is a flavonoid with a broad spectrum of biologicalactivities, including effects on metabolism, inflammation,neuroprotection, and anti-cancer properties. It acts as a potentinhibitor of CD38, a key enzyme that reduces NAD levels,thereby influencing several cell signaling pathways. Apigenin has also been shown to influenceweight, inflammation, and insulin resistance byaltering the gut microbiota and restoring therichness and diversity of the gut microbiota. Cellular Pathways Inhibition of CD38 is the core pathway formitigating age related decline. CD38 is themain enzyme that degrades NAD+. Why this matters:  CD38 is abundant in inflammatory cells and key in the decline of NAD+, crucial for cell functions. With aging, CD38 expression, mRNA, and NADase activity increase, accelerating cellular aging. Overexpression of CD38 in cancer cells triggers aging-like features. Also, low-grade inflammation during aging boosts CD38 expression in inflammatory cells, leading to their accumulat