GadoSpin™ D

GadoSpin D is a unique dendritic MRI agent for studying blood vessel integrity and angiogenesis in tumors and inflamed tissues via dynamic contrast-enhanced (DCE) MRI. It contains 24 gadolinium ions in a globular structure. The unique dendritic MRI agent: Has an intermediate molecular weight optimized for vascular studies Stays confined within intact vasculature Passes through fenestrated blood vessel in tumors and inflamed tissue Apply GadoSpin D to effectively: Quantitate angiogenesis and investigate vascular abnormalities in tumors and inflammation with ease Monitor therapeutic efficacy Use its blood pool effect for MR angiography as an alternative to GadoSpin P Physico-chemical properties and structure Relaxivity (37 °C, 1.5T) In plasma: r1 = 19 L mmol-1 s-1r2 = 29 L mmol-1 s-1 In water: r1 = 17 L mmol-1 s-1r2 = 22 L mmol-1 s-1 Molecular weight: ~17,000 g mol-1 Schematic diagram of GadoSpin D: